An EPFL spin-off in the making
Cryo-electron microscopy reveals protein structures. Our products add the missing dimensions: microsecond time resolution with CryoFlash, and broader particle views with CryoShuffle. Capture fast structural changes and obtain better reconstructions with your conventional workflow.
Our products
Capture fast protein motions with CryoFlash. Add missing particle views with CryoShuffle.
Product visualization
From picture to motion picture. CryoFlash uses laser melt-and-freeze cycles to capture transient protein structures in a vitrified cryo‑EM sample, adding microsecond time resolution to your cryo‑EM experiments.
Product visualization
More views, better reconstructions. Smart tweezers apply gentle ultrasonic excitation during plunge freezing, so particles keep tumbling while they freeze.
What we do
Structures show how proteins are built. Capturing their motions reveals how they work. We build instruments that allow cryo‑EM to capture these fast motions, opening new possibilities for structural biology and drug discovery.
Revealing protein motions can expose new druggable conformations and support better-informed target selection and drug design decisions.
Alpion CryoSolutions is built on years of peer-reviewed research into microsecond time-resolved cryo‑EM from the Lorenz lab at EPFL.
Traditional time-resolved methods reach tens of milliseconds. CryoFlash is designed for the microsecond scale, where function happens.
Our methods are based on an extensive publication record.
Five applications cover the methods behind our products, three of them already published.
The underlying research was funded by the European Research Council (ERC Starting Grant) and the Swiss National Science Foundation (SNSF Consolidator Grant). Funding for company creation comes from Innosuisse (BRIDGE Proof of Concept) and an EPFL Innogrant. External testing of CryoFlash takes place at the Dubochet Center for Imaging Lausanne.
Who it is for
Offer your users new experimental capabilities without modifying your existing infrastructure. Run the experiment upstream, then collect data on your cryo‑EM microscopes.
Bring new experiments into your own laboratory with compact hardware that fits familiar sample preparation workflows.
Explore transient target conformations and the mechanisms connecting them to open new possibilities for structure-guided drug discovery.
Microsecond time resolution with CryoFlash, or overcoming preferred orientation with CryoShuffle. Join the non-binding waiting list, or tell us about your samples and we will take it from there.